Drug interactions
Atenolol-chlorthalidone + Empagliflozin
Severity: Moderate
Atenolol-chlorthalidone and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has an osmotic diuretic effect, which adds to chlorthalidone and may lead to volume depletion, hypotension and acute kidney injury. This is more likely in older patients or those with reduced renal function.
What this interaction means in plain words
Atenolol-chlorthalidone and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
Additive natriuresis and osmotic diuresis lead to intravascular volume contraction.
What to do
Assess volume status and renal function before and after starting empagliflozin. Consider reducing the diuretic dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Empagliflozin
Frequently asked questions
Can I take Atenolol-chlorthalidone with Empagliflozin?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has an osmotic diuretic effect, which adds to chlorthalidone and may lead to volume depletion, hypotension and acute kidney injury. This is more likely in older patients or those with reduced renal function.
How serious is the interaction between Atenolol-chlorthalidone and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting empagliflozin. Consider reducing the diuretic dose if volume depletion occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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