Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has a diuretic effect, and with hydrochlorothiazide and an ARB it can cause volume depletion, hypotension and reductions in renal function. Older patients and those with reduced renal function are at greater risk.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
Additive osmotic diuresis and natriuresis from SGLT2 inhibition and thiazide action, with ARB effects on renal hemodynamics.
What to do
Assess volume status and blood pressure before and after starting empagliflozin, and consider reducing the diuretic dose if depletion is likely. Monitor renal function and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Empagliflozin
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Empagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has a diuretic effect, and with hydrochlorothiazide and an ARB it can cause volume depletion, hypotension and reductions in renal function. Older patients and those with reduced renal function are at greater risk.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and blood pressure before and after starting empagliflozin, and consider reducing the diuretic dose if depletion is likely. Monitor renal function and electrolytes.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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