Drug interactions
Azilsartan-chlorthalidone + Empagliflozin
Severity: Moderate
Azilsartan-chlorthalidone and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin adds osmotic diuresis to the combination and can enhance volume depletion and hypotension. Renal function may decline, especially in older patients or those on an ARB and diuretic.
What this interaction means in plain words
Azilsartan-chlorthalidone and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
SGLT2 inhibition produces glucosuria-related osmotic diuresis and natriuresis that is additive to thiazide-like diuretic effect.
What to do
Assess volume status and renal function before starting empagliflozin and monitor blood pressure and creatinine. Consider reducing the diuretic dose in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Empagliflozin
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Empagliflozin?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin adds osmotic diuresis to the combination and can enhance volume depletion and hypotension. Renal function may decline, especially in older patients or those on an ARB and diuretic.
How serious is the interaction between Azilsartan-chlorthalidone and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before starting empagliflozin and monitor blood pressure and creatinine. Consider reducing the diuretic dose in at-risk patients.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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