Drug interactions
Bendroflumethiazide + Empagliflozin
Severity: Moderate
Bendroflumethiazide and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote urinary fluid loss, so together they can cause volume depletion, hypotension and electrolyte disturbances. Older adults and patients with renal impairment are at greater risk.
What this interaction means in plain words
Bendroflumethiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive diuretic effect from SGLT2-mediated osmotic diuresis and thiazide inhibition of sodium reabsorption.
What to do
Assess volume status, blood pressure, electrolytes and renal function after starting. Consider reducing the diuretic dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin
Frequently asked questions
Can I take Bendroflumethiazide with Empagliflozin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote urinary fluid loss, so together they can cause volume depletion, hypotension and electrolyte disturbances. Older adults and patients with renal impairment are at greater risk.
How serious is the interaction between Bendroflumethiazide and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status, blood pressure, electrolytes and renal function after starting. Consider reducing the diuretic dose if volume depletion occurs.
What other medicines interact with Empagliflozin?
MediHelp also lists interactions of Empagliflozin with, for example, Amiloride, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Empagliflozin page.
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