Drug interactions
Aminolevulinic acid + Oxaprozin
Severity: Moderate
Aminolevulinic acid and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral aminolevulinic acid causes protoporphyrin IX accumulation and skin photosensitivity. Oxaprozin is a notably phototoxic NSAID, so the combination may increase the risk of phototoxic skin reactions.
What this interaction means in plain words
Aminolevulinic acid and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aminolevulinic acid belongs to Miscellaneous; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive phototoxic effects from two photosensitising agents.
What to do
Avoid oxaprozin and other photosensitisers for the perioperative period around aminolevulinic acid dosing and use a different analgesic. Counsel the patient on strict light protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Aminolevulinic acid
- Acitretin + Aminolevulinic acid Major
- Aminolevulinic acid + Doxycycline Major
- Aminolevulinic acid + Isotretinoin Major
- Aminolevulinic acid + Amiodarone Moderate
- Aminolevulinic acid + Amlodipine-hydrochlorothiazide-valsartan Moderate
- Aminolevulinic acid + Amlodipine-olmesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Aminolevulinic acid with Oxaprozin?
MediHelp rates the interaction as moderate. Aminolevulinic acid and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aminolevulinic acid causes protoporphyrin IX accumulation and skin photosensitivity. Oxaprozin is a notably phototoxic NSAID, so the combination may increase the risk of phototoxic skin reactions.
How serious is the interaction between Aminolevulinic acid and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oxaprozin and other photosensitisers for the perioperative period around aminolevulinic acid dosing and use a different analgesic. Counsel the patient on strict light protection.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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