Drug interactions
Aminolevulinic acid + Tolazamide
Severity: Moderate
Aminolevulinic acid and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral aminolevulinic acid used for visualization in surgery causes transient skin photosensitivity. Sulfonylureas such as tolazamide can also cause photosensitivity reactions in some patients, so the phototoxic risk may be additive in the perioperative period.
What this interaction means in plain words
Aminolevulinic acid and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aminolevulinic acid belongs to Miscellaneous; Tolazamide belongs to Endocrine.
Why it happens
Additive photosensitizing effects (pharmacodynamic) of protoporphyrin accumulation and sulfonylurea-related photosensitivity.
What to do
Counsel the patient to avoid sunlight and bright indoor light exposure for the period specified in the aminolevulinic acid labeling. Where possible, avoid starting other phototoxic agents in the 24 hours around the procedure and monitor the skin for reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Aminolevulinic acid
- Acitretin + Aminolevulinic acid Major
- Aminolevulinic acid + Doxycycline Major
- Aminolevulinic acid + Isotretinoin Major
- Aminolevulinic acid + Amiodarone Moderate
- Aminolevulinic acid + Amlodipine-hydrochlorothiazide-valsartan Moderate
- Aminolevulinic acid + Amlodipine-olmesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Aminolevulinic acid with Tolazamide?
MediHelp rates the interaction as moderate. Aminolevulinic acid and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aminolevulinic acid used for visualization in surgery causes transient skin photosensitivity. Sulfonylureas such as tolazamide can also cause photosensitivity reactions in some patients, so the phototoxic risk may be additive in the perioperative period.
How serious is the interaction between Aminolevulinic acid and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid sunlight and bright indoor light exposure for the period specified in the aminolevulinic acid labeling. Where possible, avoid starting other phototoxic agents in the 24 hours around the procedure and monitor the skin for reactions.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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