Drug interactions
Amiodarone + Avanafil
Severity: Moderate
Amiodarone and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can weakly to moderately inhibit CYP3A4, which may raise avanafil exposure. Higher levels may increase hypotension, flushing and headache.
What this interaction means in plain words
Amiodarone and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated avanafil metabolism by amiodarone.
What to do
Keep avanafil at the lowest effective dose, not above 50 mg per 24 hours as advised for moderate CYP3A4 inhibitors, and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Avanafil?
MediHelp rates the interaction as moderate. Amiodarone and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone can weakly to moderately inhibit CYP3A4, which may raise avanafil exposure. Higher levels may increase hypotension, flushing and headache.
How serious is the interaction between Amiodarone and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep avanafil at the lowest effective dose, not above 50 mg per 24 hours as advised for moderate CYP3A4 inhibitors, and monitor blood pressure.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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