Drug interactions
Amiodarone + Disopyramide
Severity: Major
Amiodarone and Disopyramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are class I/III antiarrhythmics that prolong the QT interval, and combined use markedly raises the risk of torsades de pointes. Disopyramide may also depress myocardial contractility.
What this interaction means in plain words
Amiodarone and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Disopyramide belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization and conduction.
What to do
Avoid the combination unless no alternative exists. If used, monitor ECG continuously or frequently, with electrolyte correction and careful assessment of cardiac function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Amiodarone with Disopyramide?
MediHelp rates the interaction as major. Amiodarone and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are class I/III antiarrhythmics that prolong the QT interval, and combined use markedly raises the risk of torsades de pointes. Disopyramide may also depress myocardial contractility.
How serious is the interaction between Amiodarone and Disopyramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless no alternative exists. If used, monitor ECG continuously or frequently, with electrolyte correction and careful assessment of cardiac function.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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