Drug interactions
Amiodarone + Elagolix
Severity: Minor
Amiodarone and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower amiodarone concentrations, potentially reducing antiarrhythmic effect. It also has transporter effects that could modestly alter exposure.
What this interaction means in plain words
Amiodarone and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Elagolix belongs to Musculoskeletal.
Why it happens
Elagolix induces CYP3A4, which may increase amiodarone metabolism.
What to do
Monitor for loss of rhythm control and consider checking ECG if elagolix is started or stopped in a patient on stable amiodarone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Amiodarone with Elagolix?
MediHelp rates the interaction as minor. Amiodarone and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower amiodarone concentrations, potentially reducing antiarrhythmic effect. It also has transporter effects that could modestly alter exposure.
How serious is the interaction between Amiodarone and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of rhythm control and consider checking ECG if elagolix is started or stopped in a patient on stable amiodarone.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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