Drug interactions
Amiodarone + Ivermectin
Severity: Minor
Amiodarone and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein, which limits ivermectin entry into tissues including the brain. Higher ivermectin exposure is theoretically possible, but clinical consequences are unlikely at standard doses.
What this interaction means in plain words
Amiodarone and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Ivermectin belongs to Anti Parasitic.
Why it happens
Amiodarone inhibits P-glycoprotein efflux of ivermectin, which may increase its exposure.
What to do
No routine adjustment is needed; watch for neurological adverse effects such as dizziness or confusion if high or repeated ivermectin doses are given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Ivermectin?
MediHelp rates the interaction as minor. Amiodarone and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits P-glycoprotein, which limits ivermectin entry into tissues including the brain. Higher ivermectin exposure is theoretically possible, but clinical consequences are unlikely at standard doses.
How serious is the interaction between Amiodarone and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for neurological adverse effects such as dizziness or confusion if high or repeated ivermectin doses are given.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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