Drug interactions
Amiodarone + Tucatinib
Severity: Moderate
Amiodarone and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and may increase amiodarone exposure. Amiodarone has a narrow therapeutic index, so higher levels may increase bradycardia, QT prolongation or other toxicity.
What this interaction means in plain words
Amiodarone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein by tucatinib reduces amiodarone efflux.
What to do
Monitor ECG, heart rate and signs of amiodarone toxicity. Consider reducing the amiodarone dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Amiodarone with Tucatinib?
MediHelp rates the interaction as moderate. Amiodarone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein and may increase amiodarone exposure. Amiodarone has a narrow therapeutic index, so higher levels may increase bradycardia, QT prolongation or other toxicity.
How serious is the interaction between Amiodarone and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and signs of amiodarone toxicity. Consider reducing the amiodarone dose if adverse effects emerge.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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