Drug interactions
Amiodarone + Vilazodone
Severity: Moderate
Amiodarone and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may modestly increase vilazodone concentrations, raising the risk of serotonergic and gastrointestinal adverse effects. Both drugs may also contribute to QT effects in susceptible patients.
What this interaction means in plain words
Amiodarone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Vilazodone belongs to Central Nervous System.
Why it happens
Amiodarone weakly to moderately inhibits CYP3A4, reducing vilazodone clearance.
What to do
Monitor for vilazodone adverse effects and reduce the dose to 20 mg daily if intolerable effects occur. Consider ECG monitoring in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Amiodarone with Vilazodone?
MediHelp rates the interaction as moderate. Amiodarone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may modestly increase vilazodone concentrations, raising the risk of serotonergic and gastrointestinal adverse effects. Both drugs may also contribute to QT effects in susceptible patients.
How serious is the interaction between Amiodarone and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vilazodone adverse effects and reduce the dose to 20 mg daily if intolerable effects occur. Consider ECG monitoring in patients with QT risk factors.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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