Drug interactions
Amisulpride + Chlorpheniramine
Severity: Moderate
Amisulpride and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine that can add to the drowsiness caused by amisulpride. This may impair alertness and coordination.
What this interaction means in plain words
Amisulpride and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Chlorpheniramine belongs to Respiratory.
Why it happens
Additive central nervous system depression through antihistaminic and antipsychotic effects.
What to do
Warn patients about sedation and avoid driving or alcohol. Consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Amisulpride with Chlorpheniramine?
MediHelp rates the interaction as moderate. Amisulpride and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine that can add to the drowsiness caused by amisulpride. This may impair alertness and coordination.
How serious is the interaction between Amisulpride and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and avoid driving or alcohol. Consider a non-sedating antihistamine if one is needed.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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