Drug interactions
Amisulpride + Deutetrabenazine
Severity: Moderate
Amisulpride and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride prolongs the QT interval in a dose-dependent way, and deutetrabenazine may add a small QT effect, especially at higher exposures. Both can also cause sedation. Risk of torsades de pointes is greater with bradycardia, hypokalemia, hypomagnesemia or congenital long QT.
What this interaction means in plain words
Amisulpride and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive CNS depression; amisulpride blocks cardiac repolarizing potassium channels.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and repeat the ECG after dose changes. Avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amisulpride and Deutetrabenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Amisulpride with Deutetrabenazine?
MediHelp rates the interaction as moderate. Amisulpride and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amisulpride prolongs the QT interval in a dose-dependent way, and deutetrabenazine may add a small QT effect, especially at higher exposures. Both can also cause sedation. Risk of torsades de pointes is greater with bradycardia, hypokalemia, hypomagnesemia or congenital long QT.
How serious is the interaction between Amisulpride and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and repeat the ECG after dose changes. Avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
