Drug interactions
Amisulpride + Eszopiclone
Severity: Moderate
Amisulpride and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, so concurrent use may increase drowsiness, dizziness and impaired psychomotor performance. Falls and next-day impairment are the practical concerns, particularly in older adults.
What this interaction means in plain words
Amisulpride and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Eszopiclone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective eszopiclone dose and monitor for oversedation and falls. Advise against driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Eszopiclone?
MediHelp rates the interaction as moderate. Amisulpride and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, so concurrent use may increase drowsiness, dizziness and impaired psychomotor performance. Falls and next-day impairment are the practical concerns, particularly in older adults.
How serious is the interaction between Amisulpride and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eszopiclone dose and monitor for oversedation and falls. Advise against driving until the combined effect is known.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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