Drug interactions
Amisulpride + Fostemsavir
Severity: Moderate
Amisulpride and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir causes QT prolongation at supratherapeutic doses, and amisulpride also lengthens the QT interval. The combination may add to arrhythmia risk, mainly when fostemsavir exposure is raised.
What this interaction means in plain words
Amisulpride and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Fostemsavir belongs to Anti Virals.
Why it happens
Additive effects on cardiac repolarization; fostemsavir QT effect occurs mainly at exposures above those from the recommended dose.
What to do
Obtain a baseline ECG and repeat if risk factors such as electrolyte disturbance or interacting CYP3A inhibitors are present. Correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Amisulpride with Fostemsavir?
MediHelp rates the interaction as moderate. Amisulpride and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir causes QT prolongation at supratherapeutic doses, and amisulpride also lengthens the QT interval. The combination may add to arrhythmia risk, mainly when fostemsavir exposure is raised.
How serious is the interaction between Amisulpride and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat if risk factors such as electrolyte disturbance or interacting CYP3A inhibitors are present. Correct potassium and magnesium.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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