Drug interactions
Amisulpride + Levetiracetam
Severity: Moderate
Amisulpride and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, dizziness and psychomotor slowing, so combined use may intensify these effects. Antipsychotics may also lower seizure threshold, which is relevant in patients treated for epilepsy.
What this interaction means in plain words
Amisulpride and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; amisulpride may also lower seizure threshold, opposing levetiracetam.
What to do
Monitor for excessive sedation and for changes in seizure frequency, and start amisulpride at a low dose. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Levetiracetam?
MediHelp rates the interaction as moderate. Amisulpride and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, dizziness and psychomotor slowing, so combined use may intensify these effects. Antipsychotics may also lower seizure threshold, which is relevant in patients treated for epilepsy.
How serious is the interaction between Amisulpride and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and for changes in seizure frequency, and start amisulpride at a low dose. Counsel patients about driving and operating machinery.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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