Drug interactions
Amisulpride + Methohexital
Severity: Moderate
Amisulpride and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic and amisulpride can add to its sedative and hypotensive effects. This may deepen anesthesia or prolong recovery.
What this interaction means in plain words
Amisulpride and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and dopamine D2 antagonism.
What to do
Titrate methohexital to effect and monitor airway, ventilation and blood pressure. Expect a possible prolonged recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Amisulpride with Methohexital?
MediHelp rates the interaction as moderate. Amisulpride and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic and amisulpride can add to its sedative and hypotensive effects. This may deepen anesthesia or prolong recovery.
How serious is the interaction between Amisulpride and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital to effect and monitor airway, ventilation and blood pressure. Expect a possible prolonged recovery.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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