Drug interactions
Amisulpride + Oxymorphone
Severity: Moderate
Amisulpride and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride can cause sedation and hypotension, and oxymorphone adds CNS and respiratory depression. Amisulpride also prolongs the QT interval, which matters in patients with other risk factors.
What this interaction means in plain words
Amisulpride and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects from opioid agonism and dopamine antagonist sedation.
What to do
Use the lowest effective oxymorphone dose and monitor sedation, respiratory rate and blood pressure. Check ECG and electrolytes if other QT-prolonging risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Oxymorphone?
MediHelp rates the interaction as moderate. Amisulpride and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amisulpride can cause sedation and hypotension, and oxymorphone adds CNS and respiratory depression. Amisulpride also prolongs the QT interval, which matters in patients with other risk factors.
How serious is the interaction between Amisulpride and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oxymorphone dose and monitor sedation, respiratory rate and blood pressure. Check ECG and electrolytes if other QT-prolonging risks are present.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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