Drug interactions
Amisulpride + Tolcapone
Severity: Minor
Amisulpride and Tolcapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone is a COMT inhibitor used with levodopa and is not a recognized sedative on its own, though dopaminergic therapy can cause somnolence. The more relevant concern is that amisulpride's dopamine antagonism opposes the dopaminergic therapy used in Parkinson's disease.
What this interaction means in plain words
Amisulpride and Tolcapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amisulpride belongs to Central Nervous System; Tolcapone belongs to Central Nervous System.
Why it happens
No established sedative interaction; amisulpride's dopamine receptor blockade pharmacodynamically opposes dopaminergic treatment.
What to do
Avoid amisulpride in Parkinson's disease where possible and monitor for worsening motor symptoms if it is used. Otherwise no sedation-specific action is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Amisulpride with Tolcapone?
MediHelp rates the interaction as minor. Amisulpride and Tolcapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolcapone is a COMT inhibitor used with levodopa and is not a recognized sedative on its own, though dopaminergic therapy can cause somnolence. The more relevant concern is that amisulpride's dopamine antagonism opposes the dopaminergic therapy used in Parkinson's disease.
How serious is the interaction between Amisulpride and Tolcapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid amisulpride in Parkinson's disease where possible and monitor for worsening motor symptoms if it is used. Otherwise no sedation-specific action is needed.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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