Drug interactions
Amitriptyline + Vasopressin
Severity: Minor
Amitriptyline and Vasopressin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can be associated with hyponatremia and SIADH, and vasopressin has antidiuretic activity, so the water-retaining effect may be additive. Tricyclics may also have cardiovascular effects that overlap with the pressor action of vasopressin.
What this interaction means in plain words
Amitriptyline and Vasopressin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Vasopressin belongs to Endocrine.
Why it happens
Additive antidiuretic effect and possible pharmacodynamic overlap on vascular tone; mechanism not firmly established.
What to do
Monitor serum sodium and fluid balance when vasopressin is given to patients on amitriptyline. Monitor blood pressure and heart rhythm during vasopressin infusion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clomipramine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
Frequently asked questions
Can I take Amitriptyline with Vasopressin?
MediHelp rates the interaction as minor. Amitriptyline and Vasopressin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants can be associated with hyponatremia and SIADH, and vasopressin has antidiuretic activity, so the water-retaining effect may be additive. Tricyclics may also have cardiovascular effects that overlap with the pressor action of vasopressin.
How serious is the interaction between Amitriptyline and Vasopressin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and fluid balance when vasopressin is given to patients on amitriptyline. Monitor blood pressure and heart rhythm during vasopressin infusion.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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