Drug interactions
Amlodipine + Avanafil
Severity: Moderate
Amlodipine and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak-to-moderate CYP3A4 inhibitor and also lowers blood pressure, so avanafil may cause greater blood pressure reduction than expected. Dizziness or symptomatic hypotension can occur.
What this interaction means in plain words
Amlodipine and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilation, with possible small increase in avanafil exposure via CYP3A4 inhibition.
What to do
Monitor blood pressure when starting avanafil and counsel on orthostatic symptoms. Reduce the dose or review antihypertensives if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Avanafil?
MediHelp rates the interaction as moderate. Amlodipine and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak-to-moderate CYP3A4 inhibitor and also lowers blood pressure, so avanafil may cause greater blood pressure reduction than expected. Dizziness or symptomatic hypotension can occur.
How serious is the interaction between Amlodipine and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting avanafil and counsel on orthostatic symptoms. Reduce the dose or review antihypertensives if hypotension develops.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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