Drug interactions
Amlodipine-atorvastatin + Amobarbital
Severity: Moderate
Amlodipine-atorvastatin and Amobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may lower amlodipine and atorvastatin concentrations, reducing their effects. Barbiturates may also add to hypotension and sedation.
What this interaction means in plain words
Amlodipine-atorvastatin and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Amobarbital belongs to Central Nervous System.
Why it happens
Barbiturates induce hepatic CYP3A4, increasing metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid response when amobarbital is started or stopped, and increase doses if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Amobarbital?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may lower amlodipine and atorvastatin concentrations, reducing their effects. Barbiturates may also add to hypotension and sedation.
How serious is the interaction between Amlodipine-atorvastatin and Amobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid response when amobarbital is started or stopped, and increase doses if control is lost.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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