Drug interactions
Amlodipine-atorvastatin + Atogepant
Severity: Minor
Amlodipine-atorvastatin and Atogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is cleared mainly by CYP3A4, and atorvastatin is a weak CYP3A4 substrate with amlodipine a weak inhibitor. Any rise in atogepant exposure is likely small, but it could increase adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Amlodipine-atorvastatin and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-atorvastatin belongs to Cardiovascular; Atogepant belongs to Central Nervous System.
Why it happens
Amlodipine is a weak CYP3A4 inhibitor and may slightly reduce atogepant metabolism.
What to do
No dose change is usually needed; monitor for atogepant adverse effects such as constipation and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Amlodipine-atorvastatin with Atogepant?
MediHelp rates the interaction as minor. Amlodipine-atorvastatin and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is cleared mainly by CYP3A4, and atorvastatin is a weak CYP3A4 substrate with amlodipine a weak inhibitor. Any rise in atogepant exposure is likely small, but it could increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Amlodipine-atorvastatin and Atogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for atogepant adverse effects such as constipation and nausea.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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