Drug interactions
Amlodipine-atorvastatin + Avapritinib
Severity: Moderate
Amlodipine-atorvastatin and Avapritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and amlodipine is only a weak CYP3A4 inhibitor. Exposure to avapritinib may rise modestly, potentially increasing cognitive effects, edema and bleeding risk. Avapritinib is also a CYP3A4 inhibitor/inducer-type agent that may alter amlodipine and atorvastatin levels.
What this interaction means in plain words
Amlodipine-atorvastatin and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Avapritinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by amlodipine may reduce avapritinib clearance, and avapritinib may in turn alter CYP3A4 substrate exposure.
What to do
Monitor for avapritinib adverse effects such as cognitive changes, peripheral edema and bleeding, and for blood pressure and statin-related myopathy; reduce avapritinib per labeling if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Avapritinib
Frequently asked questions
Can I take Amlodipine-atorvastatin with Avapritinib?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib is a CYP3A4 substrate, and amlodipine is only a weak CYP3A4 inhibitor. Exposure to avapritinib may rise modestly, potentially increasing cognitive effects, edema and bleeding risk. Avapritinib is also a CYP3A4 inhibitor/inducer-type agent that may alter amlodipine and atorvastatin levels.
How serious is the interaction between Amlodipine-atorvastatin and Avapritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib adverse effects such as cognitive changes, peripheral edema and bleeding, and for blood pressure and statin-related myopathy; reduce avapritinib per labeling if toxicity occurs.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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