Drug interactions
Amlodipine-atorvastatin + Bosentan
Severity: Moderate
Amlodipine-atorvastatin and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower concentrations of both amlodipine and atorvastatin. This could reduce blood pressure control and lipid-lowering efficacy.
What this interaction means in plain words
Amlodipine-atorvastatin and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induction of CYP3A4 increases metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid levels after starting or changing bosentan, and increase doses of amlodipine or atorvastatin if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Bosentan?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower concentrations of both amlodipine and atorvastatin. This could reduce blood pressure control and lipid-lowering efficacy.
How serious is the interaction between Amlodipine-atorvastatin and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid levels after starting or changing bosentan, and increase doses of amlodipine or atorvastatin if response is inadequate.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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