Drug interactions
Amlodipine-atorvastatin + Crizotinib
Severity: Moderate
Amlodipine-atorvastatin and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and can raise amlodipine and atorvastatin exposure. Crizotinib also causes bradycardia, which may be compounded by calcium channel blockers.
What this interaction means in plain words
Amlodipine-atorvastatin and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure, heart rate and muscle symptoms, and reduce the amlodipine or atorvastatin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Crizotinib?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and can raise amlodipine and atorvastatin exposure. Crizotinib also causes bradycardia, which may be compounded by calcium channel blockers.
How serious is the interaction between Amlodipine-atorvastatin and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and muscle symptoms, and reduce the amlodipine or atorvastatin dose if adverse effects occur.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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