Drug interactions
Amlodipine-atorvastatin + Dasatinib
Severity: Minor
Amlodipine-atorvastatin and Dasatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak time-dependent CYP3A4 inhibitor and may modestly raise exposure to amlodipine and atorvastatin. This could increase hypotension, edema or statin muscle toxicity, and dasatinib itself can cause fluid retention.
What this interaction means in plain words
Amlodipine-atorvastatin and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-atorvastatin belongs to Cardiovascular; Dasatinib belongs to Oncology.
Why it happens
Dasatinib inhibits CYP3A4, reducing the clearance of amlodipine and atorvastatin.
What to do
Monitor blood pressure and peripheral edema, and ask about myalgia; adjust doses only if effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Dasatinib?
MediHelp rates the interaction as minor. Amlodipine-atorvastatin and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak time-dependent CYP3A4 inhibitor and may modestly raise exposure to amlodipine and atorvastatin. This could increase hypotension, edema or statin muscle toxicity, and dasatinib itself can cause fluid retention.
How serious is the interaction between Amlodipine-atorvastatin and Dasatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and peripheral edema, and ask about myalgia; adjust doses only if effects emerge.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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