Drug interactions
Amlodipine-atorvastatin + Dronedarone
Severity: Moderate
Amlodipine-atorvastatin and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and raises amlodipine and atorvastatin exposure. It also slows sinus and AV node conduction, which may be potentiated by calcium channel blockers.
What this interaction means in plain words
Amlodipine-atorvastatin and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4 and P-glycoprotein, and has additive effects on nodal conduction and blood pressure.
What to do
Monitor ECG, heart rate and blood pressure, and watch for myopathy symptoms. Use a low amlodipine dose initially and adjust.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Dronedarone?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP3A4 and raises amlodipine and atorvastatin exposure. It also slows sinus and AV node conduction, which may be potentiated by calcium channel blockers.
How serious is the interaction between Amlodipine-atorvastatin and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure, and watch for myopathy symptoms. Use a low amlodipine dose initially and adjust.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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