Drug interactions
Amlodipine-atorvastatin + Flibanserin
Severity: Moderate
Amlodipine-atorvastatin and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may raise flibanserin exposure, especially when several weak inhibitors are taken together. Higher flibanserin levels increase the risk of hypotension, syncope and CNS depression.
What this interaction means in plain words
Amlodipine-atorvastatin and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Flibanserin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4-mediated flibanserin metabolism by amlodipine.
What to do
Monitor for dizziness, hypotension, somnolence and syncope, particularly if other CYP3A4 inhibitors are also used. Counsel the patient to avoid alcohol and to take flibanserin at bedtime.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Flibanserin?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may raise flibanserin exposure, especially when several weak inhibitors are taken together. Higher flibanserin levels increase the risk of hypotension, syncope and CNS depression.
How serious is the interaction between Amlodipine-atorvastatin and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension, somnolence and syncope, particularly if other CYP3A4 inhibitors are also used. Counsel the patient to avoid alcohol and to take flibanserin at bedtime.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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