Drug interactions
Amlodipine-atorvastatin + Fluconazole
Severity: Moderate
Amlodipine-atorvastatin and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4 and can raise amlodipine and atorvastatin concentrations. This may cause hypotension and edema from amlodipine and a higher risk of statin-related myopathy from atorvastatin.
What this interaction means in plain words
Amlodipine-atorvastatin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibition of CYP3A4 reduces the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and watch for muscle pain, weakness or dark urine during fluconazole therapy. Consider a lower dose of the combination or a temporary statin hold if prolonged or high-dose fluconazole is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Fluconazole?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4 and can raise amlodipine and atorvastatin concentrations. This may cause hypotension and edema from amlodipine and a higher risk of statin-related myopathy from atorvastatin.
How serious is the interaction between Amlodipine-atorvastatin and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and watch for muscle pain, weakness or dark urine during fluconazole therapy. Consider a lower dose of the combination or a temporary statin hold if prolonged or high-dose fluconazole is needed.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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