Drug interactions
Amlodipine-atorvastatin + Itraconazole
Severity: Major
Amlodipine-atorvastatin and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises amlodipine and atorvastatin exposure, increasing risks of hypotension and peripheral edema, and of statin myopathy. Itraconazole also has negative inotropic effects that may add to those of calcium channel blockers, which matters in heart failure.
What this interaction means in plain words
Amlodipine-atorvastatin and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole strongly inhibits CYP3A4, reducing metabolism of amlodipine and atorvastatin, with additive negative inotropy.
What to do
Avoid the combination if possible, or reduce the amlodipine and atorvastatin doses and monitor blood pressure, edema and muscle symptoms. Consider an alternative antifungal or temporarily withholding the statin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Itraconazole?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole raises amlodipine and atorvastatin exposure, increasing risks of hypotension and peripheral edema, and of statin myopathy. Itraconazole also has negative inotropic effects that may add to those of calcium channel blockers, which matters in heart failure.
How serious is the interaction between Amlodipine-atorvastatin and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or reduce the amlodipine and atorvastatin doses and monitor blood pressure, edema and muscle symptoms. Consider an alternative antifungal or temporarily withholding the statin.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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