Drug interactions
Amlodipine-atorvastatin + Letermovir
Severity: Moderate
Amlodipine-atorvastatin and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 moderately and OATP1B1/3, raising concentrations of atorvastatin and potentially amlodipine. This increases the risk of statin myopathy and hypotension or edema.
What this interaction means in plain words
Amlodipine-atorvastatin and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and OATP1B1/3 reduces clearance of amlodipine and atorvastatin.
What to do
Limit atorvastatin dose per letermovir labeling and monitor for myopathy. Monitor blood pressure and edema for amlodipine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Letermovir?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 moderately and OATP1B1/3, raising concentrations of atorvastatin and potentially amlodipine. This increases the risk of statin myopathy and hypotension or edema.
How serious is the interaction between Amlodipine-atorvastatin and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atorvastatin dose per letermovir labeling and monitor for myopathy. Monitor blood pressure and edema for amlodipine.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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