Drug interactions
Amlodipine-atorvastatin + Lomitapide
Severity: Moderate
Amlodipine-atorvastatin and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and can raise lomitapide exposure, increasing the risk of hepatotoxicity and gastrointestinal effects. Lomitapide also requires liver monitoring with statins.
What this interaction means in plain words
Amlodipine-atorvastatin and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by amlodipine decreases lomitapide metabolism.
What to do
Monitor liver enzymes closely and keep the lomitapide dose within labeled limits for weak inhibitors. Reduce the lomitapide dose if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Lomitapide?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and can raise lomitapide exposure, increasing the risk of hepatotoxicity and gastrointestinal effects. Lomitapide also requires liver monitoring with statins.
How serious is the interaction between Amlodipine-atorvastatin and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and keep the lomitapide dose within labeled limits for weak inhibitors. Reduce the lomitapide dose if transaminases rise.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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