Drug interactions
Amlodipine-atorvastatin + Lonafarnib
Severity: Major
Amlodipine-atorvastatin and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and strong CYP3A inhibitor, which can raise atorvastatin and amlodipine levels while amlodipine may modestly raise lonafarnib. This increases risk of statin myopathy, hypotension and lonafarnib toxicity.
What this interaction means in plain words
Amlodipine-atorvastatin and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
Mutual CYP3A4 inhibition and competition, with strong inhibition by lonafarnib.
What to do
Avoid the combination if possible, or limit atorvastatin dose and monitor for muscle symptoms and CK. Keep lonafarnib at its starting dose, monitor blood pressure and ECG, and reduce amlodipine as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Lonafarnib?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a sensitive CYP3A substrate and strong CYP3A inhibitor, which can raise atorvastatin and amlodipine levels while amlodipine may modestly raise lonafarnib. This increases risk of statin myopathy, hypotension and lonafarnib toxicity.
How serious is the interaction between Amlodipine-atorvastatin and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or limit atorvastatin dose and monitor for muscle symptoms and CK. Keep lonafarnib at its starting dose, monitor blood pressure and ECG, and reduce amlodipine as needed.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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