Drug interactions
Amlodipine-atorvastatin + Lurasidone
Severity: Moderate
Amlodipine-atorvastatin and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of amlodipine. Patients may experience dizziness, syncope or falls. Amlodipine as a weak CYP3A4 inhibitor may also modestly raise lurasidone levels.
What this interaction means in plain words
Amlodipine-atorvastatin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of alpha-1 adrenergic blockade and calcium channel blockade, with minor CYP3A4 inhibition.
What to do
Monitor blood pressure, including orthostatic readings, especially when starting or increasing doses. Adjust the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Lurasidone?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of amlodipine. Patients may experience dizziness, syncope or falls. Amlodipine as a weak CYP3A4 inhibitor may also modestly raise lurasidone levels.
How serious is the interaction between Amlodipine-atorvastatin and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, especially when starting or increasing doses. Adjust the antihypertensive dose if hypotension develops.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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