Drug interactions
Amlodipine-atorvastatin + Mefloquine
Severity: Moderate
Amlodipine-atorvastatin and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can slow cardiac conduction and cause bradycardia and arrhythmias, and calcium channel blockers may add to this effect. Amlodipine's effect on conduction is limited, but caution is needed in patients with other risk factors. A pharmacokinetic increase in amlodipine is not firmly established.
What this interaction means in plain words
Amlodipine-atorvastatin and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive effects on cardiac conduction and vasodilation; a metabolic interaction is suggested but not well established.
What to do
Monitor heart rate, blood pressure and ECG in patients with conduction disease or other QT-prolonging drugs. Consider an alternative antimalarial if significant bradycardia or conduction abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Mefloquine?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can slow cardiac conduction and cause bradycardia and arrhythmias, and calcium channel blockers may add to this effect. Amlodipine's effect on conduction is limited, but caution is needed in patients with other risk factors. A pharmacokinetic increase in amlodipine is not firmly established.
How serious is the interaction between Amlodipine-atorvastatin and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with conduction disease or other QT-prolonging drugs. Consider an alternative antimalarial if significant bradycardia or conduction abnormalities develop.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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