Drug interactions
Amlodipine-atorvastatin + Ribociclib
Severity: Moderate
Amlodipine-atorvastatin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase amlodipine and atorvastatin concentrations. Ribociclib also prolongs the QT interval, so unexpected effects should be monitored.
What this interaction means in plain words
Amlodipine-atorvastatin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by ribociclib reduces the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and for muscle pain or weakness, and follow the ECG and electrolyte monitoring required for ribociclib. Reduce the statin dose if myopathy symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Ribociclib?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may increase amlodipine and atorvastatin concentrations. Ribociclib also prolongs the QT interval, so unexpected effects should be monitored.
How serious is the interaction between Amlodipine-atorvastatin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for muscle pain or weakness, and follow the ECG and electrolyte monitoring required for ribociclib. Reduce the statin dose if myopathy symptoms occur.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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