Drug interactions
Amlodipine-atorvastatin + Tacrolimus
Severity: Moderate
Amlodipine-atorvastatin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine may increase tacrolimus blood concentrations in some transplant recipients, raising the risk of nephrotoxicity and neurotoxicity. The magnitude varies between patients.
What this interaction means in plain words
Amlodipine-atorvastatin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Probable inhibition of CYP3A4-mediated tacrolimus metabolism by amlodipine, though the mechanism is not fully established.
What to do
Monitor tacrolimus trough levels and renal function when amlodipine is started or changed, and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Tacrolimus?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine may increase tacrolimus blood concentrations in some transplant recipients, raising the risk of nephrotoxicity and neurotoxicity. The magnitude varies between patients.
How serious is the interaction between Amlodipine-atorvastatin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function when amlodipine is started or changed, and adjust the tacrolimus dose accordingly.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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