Drug interactions
Amlodipine-atorvastatin + Tazemetostat
Severity: Moderate
Amlodipine-atorvastatin and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may lower concentrations of amlodipine and atorvastatin, both CYP3A4 substrates, reducing blood pressure and lipid control. Amlodipine is a weak CYP3A4 inhibitor, and any effect on tazemetostat is likely small.
What this interaction means in plain words
Amlodipine-atorvastatin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat increases metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid response and adjust doses of amlodipine or atorvastatin if efficacy falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Tazemetostat
Frequently asked questions
Can I take Amlodipine-atorvastatin with Tazemetostat?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak CYP3A4 inducer and may lower concentrations of amlodipine and atorvastatin, both CYP3A4 substrates, reducing blood pressure and lipid control. Amlodipine is a weak CYP3A4 inhibitor, and any effect on tazemetostat is likely small.
How serious is the interaction between Amlodipine-atorvastatin and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid response and adjust doses of amlodipine or atorvastatin if efficacy falls.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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