Drug interactions
Amlodipine-atorvastatin + Tecovirimat
Severity: Minor
Amlodipine-atorvastatin and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may lower exposure to amlodipine and atorvastatin. This could reduce blood pressure and cholesterol control, but the effect is expected to be modest during a short course.
What this interaction means in plain words
Amlodipine-atorvastatin and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-atorvastatin belongs to Cardiovascular; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tecovirimat increases metabolism of CYP3A4 substrates.
What to do
Monitor blood pressure during and shortly after tecovirimat treatment; no routine dose change is needed for a short course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Amlodipine-atorvastatin with Tecovirimat?
MediHelp rates the interaction as minor. Amlodipine-atorvastatin and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may lower exposure to amlodipine and atorvastatin. This could reduce blood pressure and cholesterol control, but the effect is expected to be modest during a short course.
How serious is the interaction between Amlodipine-atorvastatin and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and shortly after tecovirimat treatment; no routine dose change is needed for a short course.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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