Drug interactions
Amlodipine-atorvastatin + Voriconazole
Severity: Major
Amlodipine-atorvastatin and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and can increase exposure to both amlodipine and atorvastatin. This may cause hypotension and peripheral edema from amlodipine, and raises the risk of myopathy or rhabdomyolysis from atorvastatin.
What this interaction means in plain words
Amlodipine-atorvastatin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, reducing the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and for muscle symptoms, and consider reducing the dose of amlodipine or atorvastatin during voriconazole therapy. Consider temporarily suspending the statin or using a statin not dependent on CYP3A4 for a short course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Voriconazole?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole inhibits CYP3A4 and can increase exposure to both amlodipine and atorvastatin. This may cause hypotension and peripheral edema from amlodipine, and raises the risk of myopathy or rhabdomyolysis from atorvastatin.
How serious is the interaction between Amlodipine-atorvastatin and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for muscle symptoms, and consider reducing the dose of amlodipine or atorvastatin during voriconazole therapy. Consider temporarily suspending the statin or using a statin not dependent on CYP3A4 for a short course.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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