Drug interactions
Amlodipine-benazepril + Silodosin
Severity: Moderate
Amlodipine-benazepril and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is an alpha-1 blocker that can cause orthostatic hypotension, and combining it with an ACE inhibitor and a calcium channel blocker increases that risk. The effect is most notable at the start of therapy or after dose changes.
What this interaction means in plain words
Amlodipine-benazepril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic blood pressure lowering from alpha-1 adrenergic blockade, ACE inhibition and calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting silodosin. Advise slow positional changes and reduce doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Silodosin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin is an alpha-1 blocker that can cause orthostatic hypotension, and combining it with an ACE inhibitor and a calcium channel blocker increases that risk. The effect is most notable at the start of therapy or after dose changes.
How serious is the interaction between Amlodipine-benazepril and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting silodosin. Advise slow positional changes and reduce doses if symptomatic hypotension develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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