Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Avanafil
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor with vasodilatory action and can cause additional blood pressure reduction when used with antihypertensives. Symptomatic hypotension is possible. Amlodipine is a weak CYP3A4 inhibitor, which may slightly raise avanafil exposure.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilation via PDE5 inhibition and antihypertensive actions.
What to do
Ensure blood pressure is stable before use and start avanafil at the lowest dose. Counsel patients about dizziness and to sit or lie down if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Avanafil?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor with vasodilatory action and can cause additional blood pressure reduction when used with antihypertensives. Symptomatic hypotension is possible. Amlodipine is a weak CYP3A4 inhibitor, which may slightly raise avanafil exposure.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure blood pressure is stable before use and start avanafil at the lowest dose. Counsel patients about dizziness and to sit or lie down if symptoms occur.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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