Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Cefpirome
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Cefpirome: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are renally eliminated, and competition for tubular secretion may slightly raise concentrations. Clinical impact is expected to be small except in renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Cefpirome have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Cefpirome belongs to Anti Bacterial.
Why it happens
Competition for renal tubular organic anion secretion.
What to do
No routine adjustment is needed; dose cefpirome per renal function and monitor kidney function during diuretic therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Cefpirome?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Cefpirome have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are renally eliminated, and competition for tubular secretion may slightly raise concentrations. Clinical impact is expected to be small except in renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Cefpirome?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; dose cefpirome per renal function and monitor kidney function during diuretic therapy.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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