Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Enzalutamide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may lower amlodipine concentrations, weakening blood pressure control. The effect develops over several weeks of enzalutamide therapy and persists after stopping.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing amlodipine metabolism and reducing exposure.
What to do
Monitor blood pressure after starting enzalutamide and increase the amlodipine dose or add another agent if control is lost. Reassess the dose if enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Enzalutamide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and may lower amlodipine concentrations, weakening blood pressure control. The effect develops over several weeks of enzalutamide therapy and persists after stopping.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting enzalutamide and increase the amlodipine dose or add another agent if control is lost. Reassess the dose if enzalutamide is stopped.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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