Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Bumetanide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide and hydrochlorothiazide together produce strong diuresis with potential for hypokalemia, hyponatremia, hypomagnesemia and volume depletion. Volume depletion with an ARB also increases the risk of hypotension and renal function decline.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Bumetanide belongs to Cardiovascular.
Why it happens
Additive diuretic effect via sequential nephron blockade and potassium wasting, with ARB sensitivity to volume depletion.
What to do
Monitor electrolytes, creatinine, weight and blood pressure, particularly during initiation. Reduce diuretic doses or supplement potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Bumetanide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bumetanide and hydrochlorothiazide together produce strong diuresis with potential for hypokalemia, hyponatremia, hypomagnesemia and volume depletion. Volume depletion with an ARB also increases the risk of hypotension and renal function decline.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure, particularly during initiation. Reduce diuretic doses or supplement potassium and magnesium as needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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