Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Ceritinib
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and may increase amlodipine concentrations, potentially causing hypotension, edema or dizziness. Ceritinib can also cause bradycardia and QT prolongation, which may compound cardiovascular effects.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Ceritinib belongs to Oncology.
Why it happens
Ceritinib inhibition of CYP3A4 reduces amlodipine metabolism.
What to do
Monitor blood pressure and heart rate and watch for peripheral edema; reduce amlodipine dose if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Ceritinib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 inhibitor and may increase amlodipine concentrations, potentially causing hypotension, edema or dizziness. Ceritinib can also cause bradycardia and QT prolongation, which may compound cardiovascular effects.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and watch for peripheral edema; reduce amlodipine dose if hypotension or bradycardia develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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