Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Digoxin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase sensitivity to digoxin and may provoke arrhythmias. Olmesartan can raise potassium, so net electrolyte changes are variable.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Thiazide-induced depletion of potassium and magnesium enhances digoxin's myocardial effects.
What to do
Monitor serum potassium, magnesium and renal function, and check digoxin levels or toxicity symptoms when therapy changes. Correct electrolyte disturbances promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Digoxin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase sensitivity to digoxin and may provoke arrhythmias. Olmesartan can raise potassium, so net electrolyte changes are variable.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and renal function, and check digoxin levels or toxicity symptoms when therapy changes. Correct electrolyte disturbances promptly.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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