Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Entecavir
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Entecavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated renally by filtration and tubular secretion, and drugs affecting renal function may raise its levels. Olmesartan and hydrochlorothiazide can reduce renal function in volume-depleted patients, indirectly increasing entecavir exposure.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Entecavir belongs to Anti Virals.
Why it happens
Reduced renal function or tubular competition may decrease entecavir clearance.
What to do
Monitor renal function and adjust the entecavir dose to creatinine clearance if function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Entecavir
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Entecavir?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated renally by filtration and tubular secretion, and drugs affecting renal function may raise its levels. Olmesartan and hydrochlorothiazide can reduce renal function in volume-depleted patients, indirectly increasing entecavir exposure.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Entecavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adjust the entecavir dose to creatinine clearance if function declines.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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